Because the Angular adapter for TanStack Query is built on signals, it fully supports Zoneless!
Among Zoneless benefits are improved performance and debugging experience. For details see the Angular documentation.
Besides Zoneless, ZoneJS change detection is also fully supported.
When using Zoneless, ensure you are on Angular v19 or later to take advantage of the PendingTasks integration that keeps ApplicationRef.whenStable() in sync with ongoing queries and mutations.